Expression of ZNF804A mRNA did not correlate with antipsychotic or antidepressant exposure overall or within each diagnostic group (all P > .10), nor were these medications significant in multivariate regression models. ZNF804AE3E4 mRNA was associated with antidepressant use across all participants (1.32-fold increase, P = .001) but not within any diagnostic group. Medication history did not bias the observed fold changes of expression between diagnostic groups, but the fact that only 413 participants (279 of 371 with a psychiatric diagnosis [75.2%]) had a recorded medication history reduced statistical significance (not shown).
