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Chunk #17 — Results — Psychosis Risk SNP rs1344706 Affects Fetal ZNF804AE3E4 mRNA Expression

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Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.
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The SNP rs1344706 did not affect expression of either transcript when all participants were analyzed together. However, in a planned analysis restricted to the fetal brains given the finding by Hill and Bray,25 we found a significant effect of rs1344706 on ZNF804AE3E4 mRNA (F = 6.07; P = .02) (Figure 3), with participants homozygous for the risk T allele (n = 33) showing lower expression than G carriers (n = 9) (P = .03). In contrast, full-length ZNF804A mRNA showed no allelic effects in fetal or adult samples.