Chunk #20 — REGULATORY ELEMENTS IN THE UNTRANSLATED REGIONS — Genetic variants at the 5′UTR — RNA-binding proteins and 5′UTR regulation

Source

Genetic variants in mRNA untranslated regions.

Embedded

yes

Text

Binding of RBPs to RNA targets is mediated by a set of modular RNA-binding domains, such as the RNA recognition motif, heterogeneous nuclear RNP K-homology domain, and zinc fingers,39 while the RNA target is characterized by short, single-stranded (ss)RNA sequences, often having specific secondary structures.40