Chunk #19 — REGULATORY ELEMENTS IN THE UNTRANSLATED REGIONS — Genetic variants at the 5′UTR — RNA-binding proteins and 5′UTR regulation

Source

Genetic variants in mRNA untranslated regions.

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yes

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RBPs are key components of the ribonucleoproteins complexes (RNPs) which modulate gene expression by binding the mRNA molecules and may act in both the cytoplasm and the nucleus. RBPs regulate several phases of co- and post-transcriptional gene expression, such as RNA capping, splicing and polyadenylation, and mRNA export, localization, stability and translation.38