Chunk #6 — Methods — Case–control definitions and assessment of early smoking experiences

Source

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.

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Smokers were required to have smoked at least five cigarettes/day of ≥ 0.5 mg nicotine for ≥ 5 years and had been smoking at their current rate for the past 6 months, indicating current and sustained smoking. Never smokers were defined as having smoked between one and 100 cigarettes in their life-time without developing a pattern of regular smoking.