Chunk #7 — Methods — Case–control definitions and assessment of early smoking experiences

Source

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.

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Early smoking experiences were assessed via the Early Smoking Experiences Questionnaire (ESE) [21] asking participants to rate, retrospectively, pleasurable sensations and unpleasant sensations experienced when they smoked their first cigarette. Pleasurable and unpleasant sensations (overall), pleasurable rush or buzz, relaxation, nausea, cough and dizziness were all rated on a scale of 1 (none) to 4 (intense).