The causal estimates for HDL‐C, LDL‐C, and triglycerides from multivariable MR‐Egger when the variants were orientated with respect to HDL‐C, LDL‐C or triglycerides are presented in Table 2. Estimates of the MR‐Egger intercept are also provided for the three models. To allow for comparisons between the multivariable methods, the causal estimates from multivariable IVW are included in Table 2. The causal estimates in bold follow the recommendation outlined in Section 2.5 that the genetic variants should be orientated with respect to the risk factor‐increasing allele for the risk factor of interest.
