Chunk #29 — EXAMPLE: CAUSAL EFFECT OF HDL‐C ON CHD RISK — Varying the orientation of the genetic variants

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Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy.

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As a sensitivity analysis, the multivariable MR‐Egger method was reperformed with the genetic variants orientated with respect to the risk increasing alleles for LDL‐C and triglycerides.