Genome-wide trans-eQTL analysis showed that transcript expression of genes in SH3BP5-NR2C2 region was nominally regulated by multiple genes across the genome (data not shown). After Bonferroni correction (α=4.4×10-8), only rs7667919 in PET112L (Chromosome 4) showed significant regulatory effect on CAPN7 transcript expression in PBMC (p=7.8×10-9). Furthermore, 19 SNPs in 17 genes in brain and 5 SNPs in 5 genes in PBMC had nominal replicable trans-acting regulatory effects on all four genes in SH3BP5-NR2C2 region (5.0×10-5≤p≤4.5×10-3; data not shown).
