Among those 11 replicable risk markers, four SNPs were available for eQTL analysis, including rs1318937 and rs8225 in SH3BP5, rs735659 in CAPN7 and rs9868848 in ZFYVE20. eQTL analysis showed that all of them had nominal cis-acting regulatory effects on exon-level expression of local genes in Brain tissue and/or peripheral blood mononucleated cells (PBMCs) (0.004≤p≤0.041; Table 1 and Figure S3) and nominally regulated transcript expression of many genes across transcriptome (3.3×10-5≤p≤0.05; data not shown). After Bonferroni correction, none of these cis- and trans-acting regulatory effects remained significant.
