Our samples had a high power in detecting risk markers. For example, given that the risk allele of the most significant marker, i.e., rs7445832 (see Table S3), in the EA discovery sample had a frequency of 0.2892 in cases (n=818) and 0.2111 in controls (n=1396), our EA sample had a power of 90.1% to detect any risk marker that had a similar effect size to rs7445832 (α=5×10-7). Given that the risk allele of the most significant replicable marker, i.e., rs17040623 (see Table 1), in the AA replication sample had a frequency of 0.0.059 in cases (n=449) and 0.096 in controls (n=480), our AA sample had a power of 86.4% to detect any replicable risk marker that had a similar effect size to rs17040623 (α=0.05).
