The LD structure (Figure 1d), the gene effect directions and the gene effect sizes shown in Table 1 indicated that SH3BP5-NR2C2 region could be represented by two independent risk SNPs from two LD blocks. After regressing out the effects of the two top-ranked SNPs in each block (i.e., rs17040623 at NR2C2 and rs1318937 at SH3BP5) by conditioning on them in the regression analysis, no other SNPs remained significantly associated with the phenotype (all p > 0.05; data not shown).
