Structural brain alterations in AUD have been investigated in a large number of neuroimaging studies. Regarding GM changes, several meta-analyses highlighted specific patterns of reduced regional brain volume or density [16–18]. In recent years, the number of studies investigating the macro- and microstructure of WM by magnetic resonance imaging (MRI) methods has also increased. These studies showed WM changes in numerous locations of different fiber tracts (e.g., [19–22] and [23, 24] for review).
