2 known P2X7R antagonists demonstrated inhibition of the tracer binding to rat brain tissue sections in a dose-dependent manner.214-216 While [18F]JNJ-64413739 may be a useful tool for imaging of neuroinflammation, lack of a reference region in image analysis (ie, similar to TSPO) might hinder its use as an optimum PET radiotracer for detection of neuroinflammation.214,217 Most recently, our team has synthesized a novel 18F radioligand [18F]IUR-1601, the fluoroethyl analog of GSK1482160.218 [18F]IUR-1601 has been successfully evaluated in vitro and is currently under evaluation in 5XFAD animal model of AD. A list of all P2X7 receptor PET radioligands is presented in Table 3.
