The metabotropic P2Y receptors are a family of GPCRs with 8 subtypes: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14, with ubiquitous expression and effect in body.18,219 In the CNS, P2Y receptors are localized on neurons, microglia, astrocytes, and oligodendrocytes where they have important physiological roles in glial-cell communication, neurotransmission, and neurogenesis.220,221 The hippocampus expresses P2Y1, P2Y2, P2Y4, P2Y6, and P2Y12 receptors in addition to all the P2X receptor subtypes.67
