The chairs of the Working Group were appointed in November, 2011 and a written charge to the Working Group was approved by the ACMG Board of Directors in January, 2012. The Board charged this Working Group with evaluating the utility of making recommendations for analyzing and reporting incidental findings from sequencing in the clinical context. The Working Group was asked to generate an initial list of genes and categories of variants to be reported as incidental findings. Working group members were appointed and approved by the ACMG Board in January, 2012 and met weekly by teleconference between January and September, 2012 and by email throughout the development of this manuscript. The Working Group began by establishing general processes for accomplishing its charge. We decided to consider both broad categories of disorders as well as specific genes. The initial list of genes considered by the Working Group was derived from the genes evaluated in Green et al.10 and supplemented by a provisional list of genes13 being evaluated at the University of Washington for return of results.
