suggesting that the uPA/uPAR system may contribute to neuronal damage [85, 86]. PPP2R1B encodes a regulatory subunit of protein phosphatase 2 (PP2A), which is involved in the negative control of cell growth and division via the PI3K/AKT pathway [87]. PPP2R1B itself has also been implicated in deregulation of cell cycle and apoptosis in B-cell chronic lymphocytic leukemia [88].Table 2Top hub genes of the pink WGCNA moduleGenePink Module Membershipa log2_fold_change(SZ/Ctrl)DE p-value PLAU 1.61E-101.3860719270.0010647 PPP2R1B 4.03E-100.8770106440.0003536 FXYD5 8.24E-101.0517029560.0418776 MYSM1 1.44E-090.3216461320.0026121 TPCN1 4.75E-090.3249612430.0391725 DOCK5 5.82E-091.1512015050.0017714 SAR1A 6.27E-090.2181704730.0825168 DNAJC21 6.28E-090.2608918820.0765025 PRDM5 7.87E-090.5141860010.0412623 ENTPD4 1.05E-080.3082591610.002583 aModule membership of each gene is measured by testing significance of correlation between its gene expression and the module eigengene of a given module
