Chunk #39 — Results — Weighted Gene Coexpression Network Analysis (WGCNA) for differentially expressed gene modules

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Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion.

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The potential importance of the pink module in apoptosis was supported by functional enrichment analysis. Using the RECTOME database with Enrichr [89], we found that the pink module was significantly enriched with genes that regulate apoptosis (Fig. 3c/d), consistent with the functions of the two hub genes described above. These results suggest that 22q11.2 deletion may disrupt normal apoptotic activity, by affecting one of the MAPK signaling pathways, the PI3K/AKT pathway.