Other studies have examined the influence of MC4R in African-derived populations. Grant et al.27 evaluated the MC4R locus in a cohort of 4688 European American children and 3723 African-American children. The rs571312, rs10871777 and rs476828 (perfect surrogates for rs17782313, an SNP widely replicated in European populations) yielded odds ratios in the European American cohort of 1.137–1.145 (0.042<P<0.054) for obesity, but there was no significant association with these SNPs in the African-American cohort. However, they observed significant association with rs1942880 (P = 0.008) and rs12457166 (P = 0.013), which are located in the same LD region with rs633265 (r2 = 0.22, D’ = 0.9, P = 0.45) and rs477181 (r2 = 0.11, D’ P = 0.018) reported in this study. The shows 1, rs17782313 =a trend towards the association with BMI in our study (P = 0.08); however, there was significant heterogeneity in the effect sizes across the six cohorts (Pheterogeneity = 0.007). Additionally, the T-allele was associated with increased BMI in our study as opposed to the C-allele reported in the European populations,14 though allele frequencies are similar between the
