Two SNPs in the non-coding region of ADH1B have been associated with alcohol dependence [25]; both rs1229982 and rs1159918 are located in the proximal promoter region. Allele and genotype frequencies of rs1229982 and rs1159918 are shown in Table 1. The Single Nucleotide Polymorphism database (dbSNP; www.ncbi.nlm.nih.gov/projects/SNP) reports a total of 12 SNPs in the region between −1484 bp and −10 bp (with respect to the coding sequence start site; Figure 1).
