unreliable with DNA. Like you could say you are more likely predisposed to this based on your DNA, but that’s not a guarantee.” The men also expressed concern about genetic information and its consequences, but focused more on feeling a sense of connection to and having a clear understanding of the purpose and outcomes of the research they were participating in. One man said “It’s just not knowing, not knowing what is going on behind the curtain that is hard. That is what people are wondering. ’Cause I mean honestly, you can give your DNA to someone if you know what it’s about.” In summary, concerns voiced by women tended to be related to uncertainty about the meaning of genetic information and worries over personal and/or familial safety, while men tended to focus on informational and motivational needs. Implications of these perspectives and themes for improving the participation of Latinos in alcohol research collecting biological samples are discussed below.