The themes identified in the literature review were useful in conceptualizing the thoughts and ideas Latinos expressed about participating in alcohol research collecting biological samples. Applying these themes to Latino perspectives helps expand the meaning and definition of these themes, and their applicability to increasing Latino participation in genetics research on alcohol use. The themes that we identified in the broader literature review were all reflected in the focus group data, again with the addition of a newly emergent theme surrounding previous experience, which emerged from the focus groups.