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Chunk #14 — DISCUSSION

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Meta-analysis of genome-wide association studies of anxiety disorders.
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We conducted the largest and most comprehensive genetic study of the primary anxiety disorders (ADs) to date. Specifically, we integrated phenotypic information on GAD, PD, agoraphobia, social phobia, and specific phobias and combined this with genome-wide SNP data from nine large samples totaling over 18 000 subjects. We conducted parallel GWAS in these samples and statistically combined the results via meta-analysis, with the aim of detecting common variants that play a role in shared AD susceptibility.