Furthermore, we applied MiXeR36, which uses univariate and bivariate Gaussian mixture modeling to quantify the actual number of variants that: (1) explain 90% of the SNP heritability of ADHD and (2) overlap between ADHD and other phenotypes representing domains with high genetic correlation with ADHD (psychiatric disorders, smoking behavior, weight, reproduction, and sleep were evaluated). MiXeR considers all variants, i.e., variants with the same and opposite directions of effects. Approximately 7.3K (standard deviation (s.d.) = 324) common variants were found to influence ADHD, which is less than our estimates for SCZ (9.6K; s.d. = 199), MDD (11.7K; s.d. = 345) and ASD (10.3K; s.d. = 1,011), and less than previously reported for bipolar disorder (BD) (8.6K, s.d. = 200)18.
