The genome-wide genetic correlation (rg) of ADHD with other phenotypes was estimated using published GWASs (258 phenotypes) and GWASs of UK Biobank data (514 phenotypes), available in LDhub35. ADHD showed significant genetic correlation (P < 2 × 10−4) with 56 phenotypes representing domains previously found to have significant genetic correlations with ADHD: cognition (e.g. educational attainment rg = −0.55, s.e. = 0.021), weight/obesity (e.g. body mass index rg = 0.27, s.e. = 0.03), smoking (e.g. smoking initiation rg = 0.48; s.e = 0.07), sleep (e.g. insomnia rg = 0.46, s.e. = 0.05), reproduction (e.g. age at first birth rg = −0.65, s.e. = 0.03) and longevity (e.g. mother’s age at death rg = −0.42, s.e. = 0.07). When considering other neurodevelopmental and psychiatric disorders, autism spectrum disorder (ASD) (rg = 0.42, s.e. = 0.05), schizophrenia (SCZ) (rg = 0.17, s.e. = 0.03), major depressive disorder (MDD) (rg = 0.31, s.e. = 0.07) and cannabis use disorder (CUD) (rg = 0.61, s.e. = 0.04) were significantly correlated with ADHD (Supplementary Table 17). In UK Biobank data, ADHD demonstrated the strongest genetic correlation with a low overall health rating (rg = 0.60, s.e. = 0.2; Supplementary Table 18).
