While most GWAS publications only report the top signals, the GABRIEL study [9] released the asthma association results on all SNPs investigated, allowing an in-depth analysis. For this analysis, we did not limit the list of eSNPs to the most significant SNP for each probeset; all cis eSNPs which passed the 10% FDR for any probe-set were considered. Using this strategy 60,530 of the 567,589 GABRIEL SNPs were eSNPs in lung tissue. These 60,530 eSNPs were enriched for significant association with asthma in the GABRIEL study (Figure 4). This is consistent with previous studies showing that SNPs associated with complex traits are more likely to be eQTLs [24].
