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Chunk #58 — Methods — SNP and gene findings in the context of previous analyses — Previously reported associations for significant SNPs (PheWAS)

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Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
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Multiple resources were used to identify previously reported associations of our 30 significant SNPs with other phenotypes. We used the IEU Open GWAS project92, PheWAS analysis of GWAS ATLAS52 and the NHGRI-EBI GWAS Catalog91 and identified credible SNPs through CAUSALdb90. CAUSALdb estimates causal probabilities of all genetic variants in GWAS significant loci using three state-of-the-art fine-mapping tools including PAINTOR, CAVIARBF and FINEMAP107–110. We used default settings for our CAUSALdb queries.