To evaluate the enrichment of tissue- and cell type-specific genes in OCD genetic association signals, we applied MAGMA and partitioned LDSC. We restricted the analysis to summary statistics for SNPs with a high INFO score (>0.6) and frequency in the entire cohort (MAF > 0.01). Using MAGMA (version 1.08), we tested whether genes with the top 10% specificity in a tissue or cell type showed enrichment in gene-level genetic associations for OCD, with the 1000 Genomes Phase 3 European sample genotypes serving as the linkage disequilibrium reference panel. We used standard gene boundaries (35 kb upstream of the transcription start site to 10 kb downstream of the transcription stop site). Partitioned LDSC was used to examine whether SNPs within 100-kb regions of the top 10% specifically expressed genes were enriched for SNP-based heritability for OCD. All results were corrected for multiple testing with an FDR threshold of 0.05.
