Chunk #30 — Discussion — Limitations

Source

High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk.

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Methodologic improvements of PRS [e.g., PRS-CS, included here for comparison (48)], which obviates correction for multiple testing, and the use of SNP weights based on gene expression in PRS (66) might provide improved predictive capacity.