PGS distributions, making it challenging to determine uniform thresholds to define high or low risks in different studies. Fifth, we did not perform PGS analysis in populations of non-European ancestry because the sample sizes were small. Furthermore, for admixed populations such as those of African and Latinx ancestry, different individuals may have different proportions of admixtures, resulting in different LD patterns and carrying different disease-associated SNVs. Large numbers of samples and novel and robust PGS methods for populations of non-European ancestry are critically needed.
