Although the PGS could potentially be used to assess AUD risk, it is important to emphasize that the PGS is not intended for diagnosis or prognosis. Accurate diagnosis and prognosis rely on symptom-based assessments. We also emphasize that having a high or low PGS does not guarantee that an individual will or will not develop AUD in the future. Furthermore, the PGS does not consider nongenetic factors that are known to contribute to both AUD risk and resilience. The PGS must thus be interpreted with caution and should never be used to discriminate, to stigmatize, or to deny access to insurance and prevention or treatment programs.
