In this genetic association study, we assessed the promising application of PGS calculated using concordant SNVs to evaluate AUD risk. Future studies will aim to further improve the generalizability of PGS by testing datasets with similar AUD prevalence as in general populations. We will also develop genotyping arrays and methods to eliminate genotyping platform effects and thus allow uniform thresholds for the determination of high or low risk in populations of European ancestry. Additionally, we will develop a PGS that can be used to estimate AUD risk in populations of non-European ancestry.
