Of the subjects with predicted damaging de novo mutations in CHD8 (Table S2), subject OCD8015.p1 was diagnosed with OCD and hair-pulling disorder (trichotillomania); subject OCD8134.p1 was diagnosed with OCD, Tourette’s disorder, ADHD, and separation anxiety disorder. Of the subjects with predicted damaging de novo mutations in SCUBE1, subject 8100.p1 was diagnosed only with OCD, and subject OCD8141.p1 was diagnosed with OCD and Tourette’s disorder. Based on a structured clinical interview, no subjects in this study had a diagnosis of autism spectrum disorder or intellectual disability. The presence of Tourette’s disorder in one subject each with a CHD8 and SCUBE1 predicted damaging de novo mutation raises the question of whether these genes may play a role in the Tourette phenotype. Clinically, OCD and Tourette have high rates of comorbidity (45), and our genetic overlap analysis (Table 3, Table S6) supports the likelihood of shared genetic risk. On the other hand, the largest WES study of 802 Tourette’s disorder parent-child trios (including 37% with comorbid OCD) (24) did not find evidence for CHD8 and SCUBE1 as risk genes. Continued WES of trios
