By whole-exome sequencing of OCD parent-child trios, we have demonstrated a strong association between de novo damaging (LGD and Mis-D) coding variants and OCD cases (Table 1, Figure 2). As seen in studies of other neurodevelopmental disorders, these results can be leveraged to systematically identify OCD risk genes. In the current study, two genes, CHD8 and SCUBE1, have an FDR q<0.1, meeting criteria for high-confidence association with OCD (Table 2).
