Based on the results from two pathway analysis tools, MetaCore and IPA, our input gene list is enriched for canonical pathways related to immune response, particularly the complement system (FDR 0.13). Other enriched canonical pathways include granulocyte-macrophage colony stimulating factor (GM-CSF) signaling, neurotrophin/tyrosine kinase signaling, B cell receptor signaling, and focal adhesion kinase signaling (Table S8). With regard to biological processes, sodium ion homeostasis shows the greatest enrichment using MetaCore (FDR 3.7 × 10−7). With regard to diseases, multiple cancer-related networks show the most enrichment (FDR ~10−8–10−9) using MetaCore and IPA.
