Using our list of genes harboring de novo damaging variants in OCD (n=89), we performed exploratory analyses to determine shared underlying canonical pathways and functional connectivity. Using the GeNets algorithm, OCD genes mapping onto a meta-network displayed significantly more connectivity than expected by chance (p=0.026) (Figure S6, Table S7). An additional 68 “tier 1” candidate genes were predicted by the GeNets algorithm, based on their high network connectivity to our original 89 input genes. These candidate genes are provided for reference in Table S7. All GeNets results for this analysis are also available in interactive form here: https://www.broadinstitute.org/genets#/visualize/58d9425ea4e00291af652379.
