Using DNENRICH (42), we found significant overlap between genes harboring de novo damaging variants in OCD (n=89, excludes occurrences in controls) and several gene sets from the literature (Table 3, Table S6). Our OCD genes were significantly enriched for genes harboring de novo nonsynonymous (LGD, missense) variants in Tourette’s disorder (TD) and autism (ASD), genes achieving TADA q<0.1 in ASD, genes with genome-wide significant statistical evidence for association with developmental disorders, and genes that are targets of CHD8 in the developing human brain. There was no significant enrichment for genes harboring de novo variants in intellectual disability (ID) or schizophrenia (SCZ), and no enrichment for any class of de novo variation in unaffected siblings in the SSC (Table 3, Table S6). Overlap between OCD and TD remained significant for all mutational classes, even when omitting variants from OCD subjects with comorbid tics (Table S6).
