Next, we used the estimated number of OCD risk genes (n=335) to predict the likely future gene discovery yield as additional OCD trios are investigated by WES. Based upon 10,000 simulations at each cohort size, we predict discovery of the following numbers of risk genes as we sequence more OCD parent-child trios: 24 probable risk genes, including 11 high-confidence risk genes (24 / 11 genes) at 500 trios; 77 / 40 genes at 1,000 trios; 202 / 113 genes at 2,000 trios; 323 / 189 genes at 3,000 trios (Figure S3).
