Chunk #21 — RESULTS — Approximately 335 genes contribute to OCD risk

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De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.

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Based on OCD proband vulnerability to de novo damaging variants in our dataset, we used two methods to estimate the number of genes contributing to OCD risk. Using a maximum likelihood estimation (MLE) method (41), we determined the most likely number of genes to be 335 (Figure S2). This agrees with an alternate method based on the “unseen species problem” (39); the estimated number of OCD risk genes using this alternate method is 317 (95% CI 190–454).