We include most common data sources that are also regularly updated. This covers currently KEGG (19), Reactome (20) and WikiPathways (21); miRNA targets from miRTarBase (22) and regulatory motif matches from TRANSFAC (23); tissue specificity based on expression data from Human Protein Atlas (24); protein complexes data from CORUM (25) and human disease phenotype associations from Human Phenotype Ontology (7). Users are free to choose any combination of the provided data sources. This allows users for example to focus either on cellular components from the Gene Ontology or disease information from the Human Phenotype Ontology. For all data sources, except for two (KEGG and Transfac due to the licensing reasons), users can also download all the underlying terms and associations.
