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Chunk #12 — Results — GWAS analyses

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Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
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ADH4 c 0.723271,487−6.097.63 × 10−59.85 × 10−70.035NA0.412−−−?+1.12 × 10−9rs12299844:100239319C/T ADH1B c 0.969273,90419.544.51 × 10−744.18 × 10−55.81 × 10−170.032NA++++?4.68 × 10−85rs16127354:100258007T/C ADH1C c 0.656271,471−8.861.75 × 10−146.42 × 10−50.0220.9380.054−−−++7.90 × 10−19rs131073254:103188709C/T SLC39A8 c 0.937271,7847.602.73 × 10−140.0640.363NANA+++??2.97 × 10−14rs790610410:110497101T/C0.272270,278−5.923.15 × 10−78.72 × 10−30.3570.1950.106−−−−−3.17 × 10−9rs6190281211:113374420A/C DRD2 d 0.304271,218−5.584.99 × 10−60.0250.0150.2200.931−−−−−2.44 × 10−8rs4936277e11:113431960A/G DRD2 d 0.599274,1287.442.85 × 10−110.0734.36 × 10−40.2000.357+++++1.01 × 10−13rs142108516:53800954T/C FTO c 0.670274,3406.693.26 × 10−100.0240.5250.3320.018+++++2.17 × 10−11The loci shown represent completely independent signals after conditioning analysesA1 effect allele, A2 other allele, EAF effective allele frequency, EA European American, AA African American, LA Latino American, EAA East Asian American, SAA South Asian AmericansaHuman Genome hg19 assemblybGene nearest to the lead SNPcProtein-coding gene contains the lead SNPdProtein-coding gene nearest to the lead SNPeDifferent signal than rs61902812