Within a 1Mb range, the most significant risk SNPs in the European-American discovery sample, the Australians and their combined sample (meta-analysis), and the most significant functional SNPs in the JPT, CHB and European PBMC tissue (with effects on local gene expression), and in the European brain tissue (with effects on flanking gene expression) were all located in the 246Kb NKAIN1-SERINC2 region (Figure 1, Tables 1 and Table S213). The peak SNPs within this 246kb region in the YRI-Child, European brain tissue and PBMC tissue were the same one (i.e., rs10914350). All peak SNPs in this region across all populations were in high LD; most were in the LD Block 2. Additionally, the distributions of -log(p) values for associations in all markers throughout the entire NKAIN1-SERINC2 region were consistent across the European-American discovery sample, the Australians, the HapMap CEU-Child, CEU-Parent, JPT, YRI-Child, European Brain sample and European PBMC sample (0.264≤r≤0.704; 2.9×10−5≤p≤0.031; Table 4).
