The transcript expression of NKAIN1 was significantly regulated by TMEM178 (p=4.8×10−9), CRY1 (p=1.1×10−8), PSKH2 (p=3.1×10−8) and KDM4B (p=4.7×10−8) and the transcript expression of SERINC2 was significantly regulated by SORBS2 (p=3.1×10−8; Table S5 14). Additionally, expression of NKAIN1-SERINC2 transcripts was significantly correlated with expression of numerous alcoholism-related genes (Chang et al., 2002; Luo et al., 2003; Oroszi et al., 2005; Luo et al., 2006a; Ehringer et al., 2007; Zuo et al., 2007; Wetherill et al., 2008; Lind et al., 2009; Edenberg et al., 2010; McHugh et al., 2010), although some associations between these genes and alcoholism have not yet been well replicated. These genes were mostly from the dopaminergic, serotoninergic, cholinergic, GABAergic, glutamatergic, histaminergic, endocannabinoid, metabolic, neuropeptide and opoidergic systems (α=3.4×10−7; Table S415).
