Ten top-ranked markers located within SERINC2 or within the 5’ regulatory region of SERINC2 (Table 1), and nine replicable risk markers (Table 2) were located in transcription factor binding sites. One marker (rs4949402 in SERINC2) was located in an exonic splicing silencer or enhancer. Additionally, SERINC2 harbors numerous structural variants (see NCBI dbSNPs) that are close to alcoholism-risk SNPs identified in the present study. For example, the genome-wide significant risk SNP rs1039630 was 37bp far from a frameshift SNP rs138193519 (indel −/C) and 344–347bp far from a cluster of frameshift SNPs including rs143900963, rs3050485, rs68042003, rs56365042 and rs68140019.
