In terms of the post-hoc enrichment analyses, the finding that for EAs, the GWAS that reached FDR significance all met for brain tissues, but not others, is generally consistent with prior work for PTSD and other neuropsychiatric traits (Dalvie et al., 2021; Gelernter et al., 2019b). However, additional work is needed to better understand why only three of the GWAS (MVP PTSD Re-Experiencing, DPW GSCAN, DPW UKB) exceeded the FDR cut-off. For AAs, no GWAS exceeded the FDR threshold. It is possible that this lack of significant effects is due to the smaller sample sizes among the AA GWAS.
