This investigation attempted to advance the understanding of how the genetic associations between PTSD and alcohol phenotypes may vary depending on which phenotype is being examined. In particular, future research with larger sample sizes and better tuned reference panels are needed to have more confidence in findings that are generated for samples comprised of AA individuals or other admixed populations. Ideally, future work ought to utilize larger primary datasets and more appropriate analytic strategies for admixed populations (e.g. cov-LDSC) as they become available. The findings generated among AA samples herein are a first pass within currently available data and methods and ought to be interpreted with caution. This mismatch in admixture between reference panel and target sample can impact the precision of results including the attenuation of h2 estimates.
