Our main motivation for conducting this study was to examine the effect of the CpG island on mRNA production and liability to MD and AD. In our prior communication, we found evidence of genotype specific effects of methylation on mRNA production in an exploratory analysis [Philibert et al., 2007a]. In this study, which used a much more precise method of quantitating methylation and four times the number of cell lines, we did not find that effect and suggest that either this effect is small or that our previous finding in this respect were a false positive.
