x 10-5) and the remaining individual phenotypes (P<0.00019), respectively. LD Hub traits were supplemented with LD score regression36 analyses performed locally using updated or in-house GWAS summary statistics for traits not available at LD-hub. These include ADHD, autism15, cannabis use disorder39, cannabis use114, alcohol dependence115, drinks per week, smoking ever116, age of initiation as a regular smoker, current versus a former smoker (smoking cessation), number of cigarettes per day, smoking initiation117
