We estimated SNP-heritability (h2SNP) for iPSYCH2015 cases with depression, single-episode and recurrent depression and for the external GWAS summary statistics outlined above using LD score regression36. Genetic correlations within iPSYCH and between iPSYCH and external GWAS summary statistics was estimated using LD score regression36. In addition, the genetic correlations of depression meta-analysis, single-episode and recurrent depression with other phenotypes were, evaluated using LD score regression113 at the LD Hub38 website. We used all available phenotypes on LD Hub, but we performed analyses for the UKB traits (N=597) and the remaining individual phenotypes (N=258) separately. To make our analyses more comparable to previous publications, and to avoid overly conservative correction of the many highly correlated traits, levels of experiment-wide significance (Bonferroni correction for number of tests applied) were also established separately within the two groups, i.e. in the UKB traits (P<8.38 x 10-5) and the remaining individual phenotypes (P<0.00019), respectively. LD Hub traits were supplemented with LD score regression36 analyses performed locally using updated or in-house GWAS summary statistics for traits not available at LD-hub. These include ADHD, autism15, cannabis use
