association datasets for ischaemic stroke, including both published and unpublished studies. To identify other studies, we searched PubMed on July 30, 2012, for published genome-wide association studies in ischaemic stroke with the terms “ischaemic stroke” and “genome wide association”. The search returned studies already included by the consortium members. No further studies with ischaemic stroke as a primary endpoint were identified. Interpretation This is the largest analysis of genetic data for ischaemic stroke. This study provides evidence that common genetic variation has a role in the pathogenesis of ischaemic stroke. The genetic associations identified so far are with specific stroke subtypes, suggesting that the different subtypes of ischaemic stroke have different risk factor profiles and pathophysiological mechanisms, with potential implications for all areas of stroke research.
